Randomized, Placebo-Controlled Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Lecithin Cholesterol Acyltransferase in Acute ST-Segment-Elevation Myocardial Infarction: Results of REAL-TIMI 63B.
In a randomized trial, we examined if MEDI6012, a recombinant human lecithin-cholesterol acyltransferase, could help patients experiencing acute heart attacks. The study involved 120 patients who received either the lecithin treatment or a placebo.
After 12 weeks, we found that there was no significant reduction in heart muscle damage or plaque volume in those treated with MEDI6012 compared to the placebo group. However, the treatment was generally well tolerated without major safety concerns.
We explored how lecithin-conjugated superoxide dismutase (SOD) could help reduce heart damage caused by prolonged lack of blood flow. In our study, rats underwent a coronary occlusion for 24 hours, and we compared the effects of lecithinized SOD to unmodified SOD and other treatments.
We found that lecithinized SOD significantly decreased the area of heart damage and preserved heart cells from death. This treatment shows promise for protecting heart tissue during ischemic events, thanks to its enhanced stability and affinity for heart cell membranes.
Read More
9
Lecithinized SOD shows protective effects
Lecithinized Cu, Zn-superoxide dismutase limits the infarct size following ischemia-reperfusion injury in rat hearts in vivo.
We explored whether lecithinized superoxide dismutase (SOD) could help reduce heart damage caused by ischemia-reperfusion injuries in rats. Through a controlled study, rats experienced a period of blocked blood flow followed by reperfusion. The group treated with lecithinized SOD showed smaller areas of heart damage compared to other treatments. Although all groups had similar heart rates and blood pressure, the lecithinized SOD maintained higher levels in the heart, suggesting it has a protective benefit. However, the overall effectiveness in human heart attack scenarios remains uncertain.
Read More
Most Useful Reviews
9
Stable heart condition
18 people found this helpful
After starting this supplement for vitamin health, my partner has not had a recurrence of heart attack. Arrhythmia is stable, and my wife's trigger finger is also under control. I believe this product is making a positive difference.
Read More
9
Boosts immunity
1 people found this helpful
We get this for our dad as sunflower lecithin supports heart and liver functions, boosts immunity, and protects the brain. He seems to be in excellent heart health and has not had flu, likely due to this supplement despite not leading a healthy lifestyle.
Read More
9
Supports liver health
1 people found this helpful
Wonderful! This lecithin significantly aids my liver and heart. I take it twice a year and notice tangible benefits in my health. The quality is superb and the natural ingredients are a plus. The dosage on the package is easily manageable. The results from my health tests were encouraging. I recommend it to anyone who prioritises their health, especially for liver care.
We explored how lecithin-conjugated superoxide dismutase (SOD) could help reduce heart damage caused by prolonged lack of blood flow. In our study, rats underwent a coronary occlusion for 24 hours, and we compared the effects of lecithinized SOD to unmodified SOD and other treatments.
We found that lecithinized SOD significantly decreased the area of heart damage and preserved heart cells from death. This treatment shows promise for protecting heart tissue during ischemic events, thanks to its enhanced stability and affinity for heart cell membranes.
Read More
9
Lecithinized SOD shows protective effects
Lecithinized Cu, Zn-superoxide dismutase limits the infarct size following ischemia-reperfusion injury in rat hearts in vivo.
We explored whether lecithinized superoxide dismutase (SOD) could help reduce heart damage caused by ischemia-reperfusion injuries in rats. Through a controlled study, rats experienced a period of blocked blood flow followed by reperfusion. The group treated with lecithinized SOD showed smaller areas of heart damage compared to other treatments. Although all groups had similar heart rates and blood pressure, the lecithinized SOD maintained higher levels in the heart, suggesting it has a protective benefit. However, the overall effectiveness in human heart attack scenarios remains uncertain.
We explored the effectiveness of recombinant LCAT, a lecithin-related enzyme, in improving heart health following a heart attack. In a study with thirty patients, we measured LCAT levels and found that they decrease during acute coronary syndrome, which hampers HDL's ability to support endothelial function. Remarkably, when we added recombinant human LCAT to the patients' plasma in the lab, it restored HDL’s function to improve nitric oxide production in endothelial cells. This suggests that targeting LCAT could be a promising avenue for enhancing heart health after a heart attack.
Read More
8
Sublingual nanovesicles enhance STS delivery
Nanovesicles system for rapid-onset sublingual delivery containing sodium tanshinone IIA sulfonate: in vitro and in vivo evaluation.
We explored a new nanovesicle system designed for quick sublingual delivery of sodium tanshinone IIA sulfonate (STS). This formulation, which included soybean lecithin, propylene glycol, and penetration enhancers, demonstrated significant improvements in drug absorption rates—up to 235.8 times better than traditional methods.
In animal studies, we observed that administering STS via this system quickly alleviated symptoms of acute myocardial infarction, reducing heart damage and improving key health markers within just five minutes. Overall, this innovative delivery approach shows promise for fast-acting treatment options.
Read More
8
T-0162 mitigates heart attack damage
T-0162, a novel free radical scavenger, reduces myocardial infarct size in rabbits.
We explored how T-0162, a new free radical scavenger, could impact heart attack damage. In our study with rabbits, we compared three groups: one received lecithin, another was pre-treated with T-0162, and the last got T-0162 after a heart attack.
Our findings showed that T-0162 significantly decreased heart muscle damage after a heart attack when compared to the control group, while lecithin alone did not provide similar efficacy. Overall, T-0162 appears promising for reducing heart damage during reperfusion injury.
After starting this supplement for vitamin health, my partner has not had a recurrence of heart attack. Arrhythmia is stable, and my wife's trigger finger is also under control. I believe this product is making a positive difference.
Read More
9
Boosts immunity
1 people found this helpful
We get this for our dad as sunflower lecithin supports heart and liver functions, boosts immunity, and protects the brain. He seems to be in excellent heart health and has not had flu, likely due to this supplement despite not leading a healthy lifestyle.
Read More
9
Supports liver health
1 people found this helpful
Wonderful! This lecithin significantly aids my liver and heart. I take it twice a year and notice tangible benefits in my health. The quality is superb and the natural ingredients are a plus. The dosage on the package is easily manageable. The results from my health tests were encouraging. I recommend it to anyone who prioritises their health, especially for liver care.
Read More
7.5
Health improvement
The husband took this lecithin for three months. Initially, no effects were observed. However, over time it became evident; cholesterol levels decreased, health improved, and pain in my heart area vanished. Additionally, irritability reduced, and memory enhanced. I attribute these favourable changes to lecithin.
Read More
7
Beneficial for heart health
79 people found this helpful
Good for the heart and nervous system, although the capsules are large.
A heart attack, also known as myocardial infarction, occurs when blood flow to a part of the heart is blocked, often by a blood clot. This interruption can damage or destroy part of the heart muscle, leading to serious health complications or death if not treated promptly. Common symptoms include chest pain, shortness of breath, nausea, and lightheadedness. Risk factors include high blood pressure, high cholesterol, smoking, diabetes, and a sedentary lifestyle.
Preventing a heart attack largely revolves around maintaining a heart-healthy lifestyle. Regular exercise, a balanced diet rich in fruits, vegetables, whole grains, and lean proteins, along with managing stress, can significantly lower the risk. Furthermore, understanding your personal risk factors and engaging with healthcare professionals for regular check-ups can be crucial in both prevention and early detection. If you suspect someone is having a heart attack, it's important to call emergency services immediately, as timely treatment is vital for survival and recovery.
Lecithin is a natural substance that is found in various plant and animal tissues, primarily derived from soybeans, eggs, or sunflower seeds. It is a phospholipid, which means it contains both a hydrophilic (water-attracting) and hydrophobic (water-repellent) component. This unique structure makes lecithin an excellent emulsifier, which allows it to blend ingredients that typically don't mix well together, such as oil and water. As a result, it is commonly used in food products, cosmetics, and nutritional supplements to improve texture, stability, and shelf life.
In food products, lecithin can be found in a wide range of items, from chocolates to baked goods, providing a smoother mouthfeel and enhancing flavor distribution. Additionally, lecithin plays a role in promoting better absorption of certain nutrients in the body, which has led to its popularity as a dietary supplement. While lecithin is generally considered safe for consumption, those with soy allergies should opt for alternatives like sunflower lecithin. Whether you're a home cook looking to improve your dishes or someone interested in the potential health benefits, understanding lecithin's versatile uses can enhance your culinary and nutritional knowledge.
Based on user reviews, the time it takes to see results from sunflower lecithin can vary significantly. Some users have reported noticing improvements in their health after just a few months of regular use. For example, one user noted that after three months of taking the supplement, they observed a decrease in cholesterol levels and overall health benefits, including the cessation of pain in their heart area Read Review. Another user experienced significant differences within a few months, mentioning improvements in memory and energy levels Read Review.
However, not all users reported immediate benefits; some mentioned a lack of noticeable effects after consuming half the bottle, indicating that individual responses may vary Read Review. Generally, it appears that while some may experience changes within a month or two, others might take longer to notice positive effects. Thus, it's advisable to be patient and consistent with the supplementation while monitoring your health./>
Lecithin as a supplement for heart attacks remains a mixed bag of evidence from scientific research. One study evaluating MEDI6012, a recombinant form of lecithin, in patients who suffered acute heart attacks showed no significant reduction in heart muscle damage or plaque volume when compared to a placebo group over 12 weeks, although the treatment was generally well tolerated without safety concerns [1]. In contrast, a smaller study highlighted the potential of recombinant lecithin-related enzymes, such as LCAT, to improve heart health post-heart attack by restoring HDL function, which is beneficial for endothelial health [2].
Additionally, research involving lecithinized superoxide dismutase (SOD) demonstrated promising properties in animal studies, indicating reduced heart damage during ischemia and reperfusion events, yet the implications for human applications remain uncertain [4][5]. While some animal models showcase lecithin's potential to protect heart tissues from damage, the lack of significant findings in human studies suggests that more conclusive research is needed to establish its efficacy as a supportive therapy for heart attacks.
Based on user reviews, many individuals have reported significant improvements in various health symptoms after incorporating sunflower lecithin into their routines. For instance, one user noted that their partner has not experienced a recurrence of heart-related issues and has stabilized their arrhythmia since using the supplement Read Review. Others have experienced enhanced heart health, with one reviewer mentioning that their health tests showed encouraging results and that they felt a tangible difference in their wellbeing Read Review. A user even remarked on a marked improvement in gallbladder issues and lowered cholesterol levels, which contributed to a reduction in anxiety during episodes Read Review.
Additionally, cognitive benefits have been frequently highlighted; users have experienced sharper memory and an overall boost in energy levels Read Review. Reports also confirm its effectiveness in improving mood and reducing irritability Read Review. However, while many have enjoyed these benefits, it’s worth noting that some users didn’t see noticeable changes after using the product Read Review. This anecdotal evidence suggests that while sunflower lecithin can provide substantial health benefits for many, individual results can vary significantly.
Based on user reviews, many individuals have reported positive experiences when combining sunflower lecithin with other supplements in the context of heart health. One user indicated that after starting sunflower lecithin alongside other medications, they found significant relief from panic attacks while also noting improvements in their gallbladder issues Read Review. Another user expressed that sunflower lecithin contributed to heart health benefits, mentioning it as part of an overall regimen that included various supplements aimed at enhancing heart and brain function Read Review.
Moreover, several users highlighted the importance of a multi-faceted approach to health management. For example, one user found that the combination of sunflower lecithin with their existing health practices led to lower cholesterol levels and improved overall heart health, illustrating a synergistic effect when paired with a balanced lifestyle Read Review. While not every individual reported significant changes, many noted that sunflower lecithin complements other health strategies to foster better heart and liver functioning.
Based on user reviews, there seems to be a general consensus regarding the efficacy of lecithin in supporting heart health, although specific dosing recommendations vary. Some users have reported taking sunflower lecithin at a dosage of 1,200 milligrams daily, which is recommended for optimal nerve, brain, and muscle health. This particular dosage appears to help lower "bad" cholesterol levels while increasing "good" cholesterol, thereby reducing the risk of heart disease (Read Review). Others have mentioned taking lecithin once daily after meals without specifying a precise amount, and they still experienced positive outcomes regarding their cardiovascular conditions (Read Review).
Furthermore, users indicated that while large capsules can pose a swallowing challenge, the benefits seem compelling enough to persist with the supplement. Some have noted that consistency in taking lecithin, even if the initial effects were not immediate, resulted in substantial health improvements over time, including pain reduction and better cholesterol levels (Read Review; Read Review). It's evident that user experiences highlight the importance of adhering to a daily regimen for maximum benefit.
7.5
Health improvement
The husband took this lecithin for three months. Initially, no effects were observed. However, over time it became evident; cholesterol levels decreased, health improved, and pain in my heart area vanished. Additionally, irritability reduced, and memory enhanced. I attribute these favourable changes to lecithin.
7.5
Heightened energy
1 people found this helpful
I've been taking lecithin for a few months for both brain and heart health, and I've noticed a significant difference! My memory is sharper and my energy levels have improved, along with no side effects. It's great for liver support. I highly recommend it for a wellness boost!
4
No noticeable effect
I haven't noticed any effects after consuming half the bottle. The capsules are quite large, making them difficult to swallow. I hope to see some benefits soon. Thanks for reading my review!
9
Stable heart condition
18 people found this helpful
After starting this supplement for vitamin health, my partner has not had a recurrence of heart attack. Arrhythmia is stable, and my wife's trigger finger is also under control. I believe this product is making a positive difference.
9
Supports liver health
1 people found this helpful
Wonderful! This lecithin significantly aids my liver and heart. I take it twice a year and notice tangible benefits in my health. The quality is superb and the natural ingredients are a plus. The dosage on the package is easily manageable. The results from my health tests were encouraging. I recommend it to anyone who prioritises their health, especially for liver care.
6
Cholesterol reduction
2 people found this helpful
I have experienced gallbladder issues, but lecithin has been effective in lowering my cholesterol levels. Since starting, my previous attacks have diminished significantly, making me feel more at ease.
7.5
Panic attack relief
1 people found this helpful
After Covid, I experienced severe panic attacks, but lecithin, in conjunction with other medications, has been extremely beneficial. It also helps with my gallbladder issues, and I’ll continue taking it regularly, one capsule with each meal.
7.5
Brain support
1 people found this helpful
Sunflower Lecithin 1200mg Now is a supplement I thoroughly recommend. It's effective and easy to use, with no taste but plenty of benefits. For me, it supports brain and heart health while enhancing concentration and well-being. The large capsules may seem daunting, yet they’re simple to swallow. I recommend it to anyone seeking to boost their brain health.
9
Boosts immunity
1 people found this helpful
We get this for our dad as sunflower lecithin supports heart and liver functions, boosts immunity, and protects the brain. He seems to be in excellent heart health and has not had flu, likely due to this supplement despite not leading a healthy lifestyle.
7.5
Lowers cholesterol
Sunflower seed lecithin effectively lowers cholesterol, reducing the risk of heart disease. Nutrition experts advise a daily intake of 1,200 milligrams for optimal nerve, brain, and muscle health.
7.5
Heart muscle support
The capsules are large and should be taken upright with ample water. I take one daily post-meal. This product has assisted in lowering my cholesterol and clearing arterial plaque, while also strengthening my heart muscle. Their vitamins have consistently proven to be of good quality as we have used them for many years.
2
Lecithin treatment showed no benefit
Randomized, Placebo-Controlled Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Lecithin Cholesterol Acyltransferase in Acute ST-Segment-Elevation Myocardial Infarction: Results of REAL-TIMI 63B.
In a randomized trial, we examined if MEDI6012, a recombinant human lecithin-cholesterol acyltransferase, could help patients experiencing acute heart attacks. The study involved 120 patients who received either the lecithin treatment or a placebo.
After 12 weeks, we found that there was no significant reduction in heart muscle damage or plaque volume in those treated with MEDI6012 compared to the placebo group. However, the treatment was generally well tolerated without major safety concerns.
We explored the effectiveness of recombinant LCAT, a lecithin-related enzyme, in improving heart health following a heart attack. In a study with thirty patients, we measured LCAT levels and found that they decrease during acute coronary syndrome, which hampers HDL's ability to support endothelial function. Remarkably, when we added recombinant human LCAT to the patients' plasma in the lab, it restored HDL’s function to improve nitric oxide production in endothelial cells. This suggests that targeting LCAT could be a promising avenue for enhancing heart health after a heart attack.
We explored how lecithin-conjugated superoxide dismutase (SOD) could help reduce heart damage caused by prolonged lack of blood flow. In our study, rats underwent a coronary occlusion for 24 hours, and we compared the effects of lecithinized SOD to unmodified SOD and other treatments.
We found that lecithinized SOD significantly decreased the area of heart damage and preserved heart cells from death. This treatment shows promise for protecting heart tissue during ischemic events, thanks to its enhanced stability and affinity for heart cell membranes.
9
Lecithinized SOD shows protective effects
Lecithinized Cu, Zn-superoxide dismutase limits the infarct size following ischemia-reperfusion injury in rat hearts in vivo.
We explored whether lecithinized superoxide dismutase (SOD) could help reduce heart damage caused by ischemia-reperfusion injuries in rats. Through a controlled study, rats experienced a period of blocked blood flow followed by reperfusion. The group treated with lecithinized SOD showed smaller areas of heart damage compared to other treatments. Although all groups had similar heart rates and blood pressure, the lecithinized SOD maintained higher levels in the heart, suggesting it has a protective benefit. However, the overall effectiveness in human heart attack scenarios remains uncertain.
References
Bonaca MP, Morrow DA, Bergmark BA, Berg DD, Lima JAC, et al. Randomized, Placebo-Controlled Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Lecithin Cholesterol Acyltransferase in Acute ST-Segment-Elevation Myocardial Infarction: Results of REAL-TIMI 63B. Circulation. 2022;146:907. doi:10.1161/CIRCULATIONAHA.122.059325
Ossoli A, Simonelli S, Varrenti M, Morici N, Oliva F, et al. Recombinant LCAT (Lecithin:Cholesterol Acyltransferase) Rescues Defective HDL (High-Density Lipoprotein)-Mediated Endothelial Protection in Acute Coronary Syndrome. Arterioscler Thromb Vasc Biol. 2019;39:915. doi:10.1161/ATVBAHA.118.311987
Zhu H, Hao J, Chen H, Jiang S, Liu M, et al. Nanovesicles system for rapid-onset sublingual delivery containing sodium tanshinone IIA sulfonate: in vitro and in vivo evaluation. J Pharm Sci. 2013;102:2332. doi:10.1002/jps.23512
Nakajima H, Hangaishi M, Ishizaka N, Taguchi J, Igarashi R, et al. Lecithinized copper, zinc-superoxide dismutase ameliorates ischemia-induced myocardial damage. Life Sci. 2001;69:935.
Hangaishi M, Nakajima H, Taguchi J, Igarashi R, Hoshino J, et al. Lecithinized Cu, Zn-superoxide dismutase limits the infarct size following ischemia-reperfusion injury in rat hearts in vivo. Biochem Biophys Res Commun. 2001;285:1220.
Yamashita K, Minatoguchi S, Uno Y, Kariya T, Ohno M, et al. T-0162, a novel free radical scavenger, reduces myocardial infarct size in rabbits. Clin Exp Pharmacol Physiol. 2000;27:172.